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Amy Schumer is sharing her unfiltered weight loss journey—striking a chord. After a difficult experience with Wegovy, she’s now seeing real results with Mounjaro. The comedian, 43, got candid in an Instagram video about how the medication, along with hormone therapy, has transformed her health.
Here’s what worked for her, and what her experience reveals about today’s weight loss drug landscape.
Why Amy Schumer Says Mounjaro Worked Better Than Wegovy
Schumer didn’t hold back when describing her previous experience with Wegovy. She tried the medication several years ago to manage her weight but quickly found herself overwhelmed by the side effects.
Her issues with Wegovy included
- Persistent, intense nausea
- Episodes of vomiting
- General fatigue and discomfort
“I tried it a couple of years ago, and I was one of the people who felt sick. I couldn’t handle it,” Amy said in her video. The side effects were so severe that she had to discontinue the medication early on, a story that’s becoming more common as the popularity of GLP-1 receptor agonists grows.
In contrast, her experience with Mounjaro—another injectable weight loss drug originally developed for type 2 diabetes—has been much more positive. She reports feeling better physically and emotionally, with noticeable improvements in her energy levels and overall well-being.
Not only that, she credits her success to a more well-rounded, holistic strategy. That included addressing her perimenopausal hormone imbalances with the help of telehealth support from Midi Health, a women’s hormone health platform she now champions as both a patient and investor.
The Hormonal Factor: Why It Was a Game-Changer for Her
Amy revealed that before restarting weight loss medications, she took the time to focus on another major piece of her health puzzle—hormones. Perimenopause, the transitional phase before menopause, can dramatically impact a woman’s metabolism, mood, and weight.
Why addressing hormones made a difference for her
- Estrogen and progesterone therapy helped reduce perimenopausal symptoms like hot flashes and night sweats
- She experienced a surge in daily energy and motivation
- Hair appeared fuller, skin clearer, and libido improved
- Her overall sense of vitality returned
What Amy’s Story Reveals About Today’s Weight Loss Medications
Schumer’s honesty shows that weight loss drugs are not a one-size-fits-all solution. What works for one person might not work for another.
Key takeaways
- Side effects matter: finding the right medication is trial and error
- Combining treatments (like hormone therapy) can boost results
- Access is limited—Mounjaro is often not covered unless there’s a diabetes diagnosis
- Transparency helps reduce stigma around these meds
She also acknowledged her privilege in being able to afford and access top-tier telehealth support like Midi Health, a company she now supports as an investor.
Humor, Health, and Keeping It Authentic
Even while discussing serious health matters, Amy stayed true to her comedic roots. She made it a point to keep things light and relatable, joking about her appearance and the scrutiny that often comes with being in the public eye.
One standout moment:
“I want to commit to you that I will never get lip fillers, so you can always enjoy that I have no top lip,” she quipped.
The Bigger Picture: Health Is More Than a Number
Amy’s story isn’t just about weight loss—it’s about reclaiming her health, her energy, and her sense of self. She’s showing that success doesn’t come from chasing a specific size or number on the scale, but from feeling empowered, supported, and in tune with your body.
Her journey is a reminder that:
- Weight loss is deeply personal and should be approached with compassion and care
- Hormonal health plays a crucial role, especially for women over 40
- Transparency and support can change the narrative around these medications
- It’s okay to switch paths if one approach doesn’t work for you
Amy Schumer’s experience with Mounjaro offers a glimpse into the evolving world of weight loss treatments. By being open about her ups and downs, she’s showing that success comes from listening to your body, exploring options, and staying real through it all. Her journey reminds us that health isn’t just about numbers—it’s about feeling good in your skin
